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pentobarbital will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will reduce the level or effect of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Women shouldn't opt for estradiol valerate/dienogest as t